Taking charge

tRNAs taking charge

Most bacterial toxins derived from chromosomally encoded toxin-antitoxin (TA) systems that have been studied to date appear to protect cells from relatively short pulses of stress by triggering a reversible state of growth arrest. In contrast to many bacterial toxins that are produced as defense mechanisms and secreted from their hosts, TA toxins exert their protective effect from within the ce...

Electrochemical sensors: Taking charge of detection.

ruthenium complexes and DNA. Jacqueline Barton and co-workers2 co-crystallized Δ-[Ru(bpy)2(dppz)] with the 12-mer DNA sequence d(CGGAAATTACCG) — a self-complementary double helix with two adenine:adenine (A:A) mismatches. An atomic-resolution structure analysis of the resulting co-crystal revealed a complex pattern of interactions between the ruthenium compound and the DNA. Five individual ruth...

Taking Charge of Yourself and Your Work

Taking Charge: Feeding Malaria via Anion Channels

The human malaria parasite Plasmodium falciparum increases red blood cell membrane permeability during infection to allow for import of nutrients and other solutes. Nguitragool et al. (2011) have now identified parasite-encoded CLAG3 proteins as key components of the import channel located on the erythrocyte membrane.

Pharmacists: taking charge of minor ailments and unlocking prison health

It has been estimated that minor ailments account for as much as a third of GP consultations. This is equivalent to 300,000 consultations every day. Moreover, research suggests that minor ailments and injuries account for between 30 and 40 per cent of attendances at accident and emergency departments. Transferring minor ailments in the community from GPs to pharmacists has been shown to reduce ...